Basic information and current topics regarding Flaviviridae

Flavivirus Life Cycle Stages 1-6

Viruses belonging to the family Flaviviridae are considered class 4 viruses within the Baltimore classification scheme. Viruses in this class are positive sense, single stranded RNA viruses which replicate their genome through a partially double-stranded intermediate form.

The following sections address the life-cycle of Flaviviridae specifically, but they still fall close to the generic category of class 4 viruses. The life-cycle has been divided into several pages for your convenience:

Virus attachment, entry, and uncoating — This section overviews the proteins important to a flavivirus’ tissue tropism, the method used for entering the cell, and the strategies used for signaling viral uncoating.

Expression and biosynthesis — Here we discuss the various genes of the generic flavivirus genome and the timing related to each gene. This section overlaps with the following section’s time-line, as viral assembly and genome expression patterns are topics which happen synchronously.

Virus assembly — This page delves into the structure of Flaviviridae and how that structure is created.

Virus exit strategies — A short but conclusive section briefly describing how the Flaviviridae family leaves its host.


picture source: http://www.pnas.org/content/99/18/11555.long