Flavivirus

Basic information and current topics regarding Flaviviridae

Current Research Summaries

– April, 2011 –

Nimesh Gupta and P v Lakshmana Rao. (2011). Transcriptomic profile of host response in Japanese encephalitis virus infection. Virology Journal 2011, 8:92 doi:10.1186/1743-422X-8-92

The Article – Distributed under the Creative Commons Attribution License

The Review – Official flavivirus.wordpress.com review of the above article

Overview:

An excellent article, especially when considering the size of the research team. Target genes for future research are unveiled with a good population size and an even better methodology. Requirements for significantly different expression are stringent and quantitative data is carefully obtained. Authors take advantage of the open-access journal, publishing their entire methods with meticulous notes and a focus towards repeatability.


– April, 2011 –

Butrapet, S., Childers, T., et al. (2011). Amino acid changes within the E protein hinge region that affect dengue virus type 2 infectivity and fusion. Virology. 413: 118-127

The Article – PubMed entry for the article

The Review – Official flavivirus.wordpress.com review of above article


– April, 2011 –

Ang F., Wong P. Y., Ng M. M., Chu J. J. (2010). Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus. Virology journal (1743-422X), 7, p. 24.

The Article – Distributed under the Creative Commons Attribution License

The Review – Official flavivirus.wordpress.com review of the above article

Overview:

This is an older article, but a good starting-point for those interested in flavivirus research. A thorough background is given that highlights how important membrane traffic pathways are to flaviviruses. siRNA profiling is used to expose gene-products which contribute to successful Dengue Virus infection. Major technique used is immunofluorescence–providing pretty pictures and visual results. The researchers also translate their results in a general way, which helps to reinforce our suggestions on how the Dengue Virus works.


– April, 2011 –

Tomlinson, SM., Watowich, SJ. (2011). Anthracene-based inhibitors of dengue virus NS2B-NS3 protease. Antiviral Research. 89: 127-135

The Article – PubMed entry

The Review – Official flavivirus.wordpress.com review of the above article