Basic information and current topics regarding Flaviviridae

Virus Exit Strategies

Flaviviruses exit the cell via exocytosis. Completed nucleocapsids gather at the plasma membrane and bud out of the cell. However, not all flaviviruses exit the cell as complete packages. Many are released without a nucleocapsid or without proper cleavage of the prM proteins; see SHA/RSP in the figure below.

Flavivirus Life-cycleImage from: Chambers, T. J.,  et. al. The Flaviviruses: Structure, replication, and evolution (see references for full citation)

Given that the E proteins have already integrated into the host membrane, the prM proteins have been cleaved properly, and the nucleocapsid is present and contains a full genome copy, the flavivirus is then ready to be transmitted into nearby cells.



1. Chambers, T. J., & Monath, T. P. (January 1, 2003). The Flaviviruses: Structure, replication, and evolution. p. 65